Why Polynucleotides Are Being Called the Future of Injectables
A new injectable is gaining attention in clinics across the UK — and it’s not Botox or filler. Polynucleotides (PN), a regenerative treatment made from purified DNA fragments, are being hailed as the next big thing in aesthetics.
According to data from beauty and wellness platform Fresha, UK searches for “polynucleotides” have soared to 55,000 in the past month — a 133% year-on-year increase. Interest has been rising steadily since early 2024, fuelled by TikTok buzz, press coverage, and clients looking for natural alternatives to traditional injectables.
Why clients are asking for it
So what makes polynucleotides different? Unlike Botox, which relaxes muscles, or fillers, which add volume, PN works at a cellular level. By stimulating fibroblasts, it helps regenerate collagen and elastin — repairing skin, improving hydration, and creating results that look natural rather than dramatic.
Specialists say clients are turning to PN for:
- Skin regeneration: firmer, more youthful skin
- Improved hydration: plumper, more elastic texture
- Anti-inflammatory effect: calmer, more even skin tone
- Subtle rejuvenation: especially effective for under-eyes and neck
- Compatibility: works well with fillers, PRP, or microneedling
As one practitioner on the Fresha Marketplace explains:
“Polynucleotides are changing the game. Clients no longer want dramatic changes – they want natural improvements in skin quality. We’re seeing more requests for PN than ever before.”
The ‘next evolution’ of injectables
Botox has been the gold standard in aesthetics for decades, but PN represents a shift towards regenerative treatments.
“Botox and fillers will always have their place,” says a Fresha practitioner, “but polynucleotides are part of a bigger movement. Clients want injectables that heal, repair, and rejuvenate from within — not just freeze muscles.”
Risks and considerations
Like all injectables, PN isn’t risk-free. Common side effects include redness, swelling, or bruising at the injection site. Most treatment plans involve 2–3 sessions, with results appearing gradually.
PN isn’t suitable during pregnancy, breastfeeding, or for those with allergies to fish proteins — since the treatment is often derived from fish DNA.
The bottom line
Polynucleotides may not replace Botox overnight, but they’re quickly carving out a niche as a natural, regenerative alternative. With growing awareness and rising demand, they could mark the future of aesthetic injectables — subtle, restorative, and focused on long-term skin health.
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